Cortisol, often referred to as the "stress hormone," plays a crucial role in the body's response to stress by regulating metabolism, inflammation, and immune function. Chronically elevated cortisol levels, commonly caused by prolonged stress, can lead to negative impacts on brain health, including impaired memory, reduced hippocampal volume, and increased risk of mood disorders such as anxiety and depression. Conversely, abnormally low cortisol levels may indicate adrenal insufficiency or conditions like burnout. Monitoring cortisol levels provides valuable insights into the physiological effects of stress and helps guide interventions to mitigate its impact on neurological and overall health.
Cortisol levels can be measured through saliva, blood, urine, or hair samples. Salivary cortisol is the most common method for assessing stress, as it is non-invasive and reflects free, biologically active cortisol. Samples are often collected at multiple times throughout the day (e.g., morning, midday, evening) to observe diurnal patterns, with a peak in the morning and a gradual decline by evening. Blood tests measure total cortisol levels and are commonly used in clinical settings. Urinary cortisol provides a cumulative measure of cortisol secretion over 24 hours, while hair cortisol indicates long-term cortisol exposure over weeks or months. Each method offers unique insights depending on the context and duration of stress being assessed.