Unlocking the Full Potential of Resistance Training: A Comparative Analysis of Low- and High-Intensity Effects on Neurotrophic Growth Factors and Homocysteine

This study investigated how different intensities of resistance training affect brain health-related biomarkers. Twelve young male participants with no prior strength training experience engaged in a randomized controlled cross-over trial, completing either high-intensity (80% 1RM) or low-intensity (40% 1RM) resistance training. Blood samples showed that high-intensity training significantly increased neurotrophic factors (BDNF, IGF-1, VEGF), while both training intensities lowered homocysteine levels, which is linked to cognitive decline. The study was randomized, included a control period, and used statistical analyses showing significant effects (p < 0.05). However, its small sample size limits generalizability to broader populations.

Incorporate resistance training into your routine to support brain health, as both high- and low-intensity exercises lower homocysteine, a marker linked to cognitive decline. High-intensity workouts may provide greater boosts to neurotrophic factors, but lower-intensity training offers similar benefits with reduced injury risk. Given the study's small sample size, long-term research is needed to confirm cognitive effects. Aim for a balanced approach that aligns with your fitness level and safety considerations.