The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort

This cohort study validated the Brain Care Score (BCS), a 21-point tool assessing physical, lifestyle, and social factors to predict dementia and stroke risk. Using data from nearly 400,000 UK Biobank participants, higher BCS scores were significantly associated with reduced dementia and stroke risks, especially in younger individuals. A 5-point BCS increase correlated with 14% and 40% lower dementia and stroke risks, respectively. These findings suggest practical applications for BCS in guiding preventive brain health strategies.

Adopt healthier lifestyle choices aligned with BCS components: improve diet, maintain regular exercise, avoid smoking, moderate alcohol use, manage stress, and prioritize sleep and social connections. These changes may lower dementia and stroke risks. However, further studies are needed to validate long-term outcomes and ensure generalizability.