RESOURCE
|
January 19, 1999

Running enhances neurogenesis, learning, and long-term potentiation in mice

Research
Proceedings of the National Academy of Sciences
SUMMARY

This study investigated how running influences brain health and learning in mice. It found that voluntary running significantly increased neurogenesis (the creation of new neurons) in the hippocampus, a key area for memory and learning. Running mice performed better on spatial memory tasks (like the Morris water maze) and showed enhanced synaptic plasticity, measured as long-term potentiation (LTP), in the hippocampus. These results suggest that running not only boosts memory and learning but also promotes brain plasticity by fostering the growth and integration of new neurons into neural circuits. These findings highlight the potential for physical activity to support cognitive health and prevent age-related decline.

RECOMMENDATION

Incorporate regular aerobic activities, such as running or brisk walking, into your routine to promote brain health. This study provides strong evidence from animal models that physical-exercise enhances neurogenesis and cognitive function. While results may vary in humans, regular exercise is widely supported as beneficial for brain health, aiding in memory, learning, and mood improvement.

TAGS
neurogenesis; hippocampus; running; brain plasticity; spatial memory; synaptic plasticity; long-term potentiation; physical activity; cognitive function; mice study
DEEP DIVE