Physical Activity and Neurodegenerative Diseases: Potential Role in Prevention and Therapy

This clinical review examines how physical activity impacts the prevention and management of neurodegenerative diseases like Alzheimer’s, Parkinson’s, and dementia. Regular exercise enhances brain plasticity by promoting neurogenesis, improving vascular health, and reducing systemic inflammation. Studies show up to a 45% reduction in dementia risk and significant improvements in motor and cognitive symptoms in Parkinson's patients. Physical activity is a low-cost, non-pharmacological strategy for mitigating age-related brain decline.

Engage in 150 minutes of moderate-intensity aerobic exercise weekly, combined with strength training. Activities like dancing or cognitive-motor exercises offer additional benefits for brain plasticity. While the evidence supports these strategies, individualized exercise plans should consider specific health conditions and preferences.