Hippocampal plasticity underpins long-term cognitive gains from resistance exercise in MCI

This study explored how resistance training affects brain health in older adults with mild cognitive impairment (MCI). Over 18 months, participants who engaged in high-intensity resistance training showed better memory, executive function, and global cognition compared to controls. MRI scans revealed that resistance training preserved hippocampal subfields prone to Alzheimer’s-related atrophy, including the CA1 and subiculum. These structural changes were linked to improved cognitive performance, highlighting resistance training as a potential non-drug approach to delay neurodegeneration in MCI patients.

Incorporate resistance training into your weekly routine, focusing on exercises targeting major muscle groups at moderate to high intensity, twice or thrice weekly. This can improve cognitive functions and protect brain regions vulnerable to Alzheimer’s disease. While results are promising for MCI, broader application requires further research. Supervised training is advised for safety and to maximize cognitive and physical benefits.