Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate

This study explored how exercise increases levels of brain-derived neurotrophic factor (BDNF), a protein crucial for memory, learning, and mental health. Using animal models, researchers found that prolonged physical activity elevated BDNF expression in the hippocampus. This was linked to the production of β-hydroxybutyrate (DBHB), a molecule created during exercise, which inhibits enzymes (HDAC2 and HDAC3) that typically suppress BDNF. Elevated BDNF also enhanced neurotransmitter activity, improving brain plasticity and potentially protecting against conditions like depression and neurodegenerative diseases. These findings highlight the molecular link between physical-exercise and brain health, emphasizing its role in improving cognition and emotional well-being.

Regular aerobic exercise, such as running or cycling, can enhance brain health by increasing BDNF levels, promoting memory and resilience to stress. Aim for at least 30 minutes of moderate exercise several times a week. These findings, though based on animal models, align with broader evidence supporting exercise's cognitive and emotional benefits in humans. Consult a healthcare provider before adopting a new exercise routine, especially if you have health concerns.