Exercise-Mediated Neurogenesis in the Hippocampus via BDNF

This review explores how exercise promotes neurogenesis (the growth of new neurons) in the hippocampus, a brain region critical for memory and learning. The process is mediated by brain-derived neurotrophic factor (BDNF), a protein essential for neuron survival and connectivity. Exercise boosts BDNF levels, enhancing cognitive function and emotional health. In animal studies, increased BDNF improved learning, memory, and neuroplasticity. Human studies, while indirect, show exercise's role in boosting BDNF and its link to improved brain health. The findings highlight the molecular pathways through which physical activity combats cognitive decline, stress, and neurodegeneration.

Incorporate regular aerobic exercise, such as walking or cycling, to promote brain health by enhancing BDNF production, which supports memory and learning. Aim for at least 30 minutes, 3–5 times weekly, as moderate exercise yields optimal results. Extreme exertion may reduce benefits due to oxidative stress. While findings from animals are clear, human results are indirect, but evidence suggests exercise protects against cognitive decline and supports mental resilience.