Evidence of association between higher cardiorespiratory fitness and higher cerebral myelination in aging

This study examined the link between cardiorespiratory fitness (CRF) and brain myelination in 125 cognitively healthy adults aged 22 to 94. Using advanced MRI techniques, researchers found that higher CRF, measured by VO2max, correlated with greater myelin content in brain regions susceptible to aging-related decline, such as the frontal lobes. The association was strongest in middle-aged and older adults, suggesting that CRF may help maintain white matter integrity. While the study was cross-sectional and cannot establish causation, it provides evidence that aerobic fitness could mitigate brain aging. Limitations include the predominantly White participant sample and the absence of long-term follow-up.

To support brain health, individuals should maintain or improve CRF through regular aerobic exercise like walking, running, or cycling. While this study suggests a correlation between CRF and myelin integrity, it cannot prove causation. Still, prior research supports exercise as beneficial for neuroprotection. Other lifestyle interventions such as balanced nutrition, cognitive engagement, and adequate sleep may further enhance white matter integrity, complementing physical activity.