Aerobic physical-exercise as a Non-medical Intervention for Brain Dysfunction: State of the Art and Beyond

This research explores how aerobic physical-exercise (PE) benefits brain health by improving cognition, reducing depression, and alleviating chronic pain. PE fosters anti-inflammatory effects, promotes hippocampal plasticity, prevents neuronal loss, and enhances the brain's structural integrity. The study highlights the connection between bones and the brain ("bone-brain axis"), showing how PE triggers beneficial protein production in bones that positively impacts the brain. It provides a basis for using exercise as a non-medical intervention for neurodegenerative diseases like Alzheimer's and Parkinson's.

Engaging in regular aerobic exercise, such as walking or cycling, at moderate intensity for at least 150 minutes weekly can enhance brain health. This aligns with the study's findings but may vary across age groups and conditions. Consult a professional to tailor exercise regimens, especially if managing chronic diseases.