Vitamin D Supplementation in Multiple Sclerosis: A Critical Analysis of Potentials and Threats

This review explores the role of vitamin D supplementation in multiple sclerosis (MS), a chronic neurological condition. While low vitamin D levels are linked to increased MS risk and activity, clinical trials on supplementation have shown mixed results, with limited impact on reducing relapses or disability progression. High doses appear safe short-term but carry risks of toxicity, including kidney damage and symptoms mimicking MS. More robust research is needed to confirm its therapeutic value and optimal dosage.

Ensure adequate vitamin D levels through moderate supplementation (e.g., 600–800 IU/day) and sun exposure, especially for individuals at risk of MS or with low baseline levels. Avoid high-dose regimens unless supervised by a physician, as excessive intake can lead to serious complications without clear additional benefits.