To Keto or Not to Keto? A Systematic Review of Randomized Controlled Trials Assessing the Effects of Ketogenic Therapy on Alzheimer Disease

This systematic review analyzed randomized controlled trials (RCTs) investigating ketogenic therapies for Alzheimer’s disease (AD) and mild cognitive impairment (MCI). The review found that ketogenic diets or supplements, such as medium-chain triglycerides (MCTs), improved general cognition and memory over short- and long-term interventions. Ketone production enhanced brain energy metabolism, particularly in those without the APOE ε4 allele, while attention and executive function showed minimal changes. Despite promising findings, study designs were highly variable, requiring further standardization and research.

Incorporating ketogenic diets or MCT supplementation might benefit individuals with cognitive impairment or early AD. However, given mixed results and the need for further trials, consult a healthcare provider before starting such therapies to ensure suitability and minimize risks.