The Effect of Short-Term Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet on Hunger Hormones, Anthropometric Parameters, and Brain Structures in Middle-Aged Overweight and Obese Women: A Randomized Controlled Trial

This randomized controlled trial investigated the effects of the MIND diet—a combination of the Mediterranean and DASH diets—on weight, hunger-related hormones, and brain structures in overweight and obese middle-aged women. Over three months, participants following the MIND diet experienced significant reductions in weight, body mass index, body fat percentage, waist circumference, and leptin levels, alongside increases in ghrelin and GLP-1 levels, compared to a control group. However, no significant changes in brain structures were observed between the groups. These findings suggest that the MIND diet may positively influence metabolic health, which is crucial for maintaining cognitive function and overall brain health.

Incorporating the MIND diet into one's lifestyle—emphasizing green leafy vegetables, berries, nuts, and whole grains—may aid in weight management and improve metabolic profiles, potentially supporting brain health. However, as this study was conducted on a specific group over a short period, further research is needed to confirm these benefits across diverse populations and longer durations.