Short-term calorie restriction enhances adult hippocampal neurogenesis and remote fear memory in a Ghsr-dependent manner

This study shows that short-term calorie restriction (CR) enhances the production of new neurons in the hippocampus, a brain region critical for memory and learning, by activating the ghrelin receptor (Ghsr). CR also improved the ability to retain fear-based memories in mice. These benefits were tied to increased levels of the neurogenic transcription factor Egr-1, which helps integrate new neurons into brain circuits. This research suggests that CR promotes brain plasticity and memory via specific molecular pathways.

Incorporating short-term calorie restriction (e.g., reducing daily calorie intake by 30% for brief periods) may support brain health and memory. However, consult with a healthcare provider before starting, as long-term effects in humans and safety across populations remain under investigation.