Randomized crossover trial of a modified ketogenic diet in Alzheimer’s disease

This randomized crossover trial assessed the effects of a 12-week modified ketogenic diet (KD) on Alzheimer’s disease (AD) patients. The KD improved daily function and quality of life significantly compared to a standard low-fat diet, though cognitive improvements were not statistically significant. Participants maintained a state of ketosis, supporting brain energy through ketones rather than glucose. Changes in cardiovascular markers were mostly positive, and adverse effects were mild, suggesting the diet is safe and feasible for managing AD symptoms.

A ketogenic diet may enhance quality of life and daily function in individuals with Alzheimer’s. It is essential to adopt the diet under medical supervision, as its effects on cognition vary and individual adherence can be challenging. A gradual introduction of the diet may help ease adaptation.