Randomized Controlled Trial Effect of Short-Term MIND Diet Intervention on Hunger Hormones, Anthropometric Parameters, and Brain Structures in Middle-Aged Obese Women

This randomized controlled trial explored the effects of a short-term MIND diet intervention on weight, metabolism, and brain structure in 37 middle-aged obese women. The study found significant improvements in weight, body fat percentage, waist circumference, and hunger-related hormones (leptin, ghrelin, GLP-1) in the MIND diet group compared to a control group. Despite these positive metabolic and anthropometric changes, there were no observable differences in brain structures between the groups. The results highlight the MIND diet's potential for weight management and metabolic health but not immediate effects on brain anatomy.

Incorporating MIND diet principles, such as increasing green leafy vegetables, berries, nuts, olive oil, and limiting red meat and sweets, may support weight loss and metabolic health. While this study shows metabolic benefits, further research is needed to confirm its long-term brain health impacts.