Probiotics for Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis examined the effects of probiotics on cognitive function in individuals with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Among the studies, probiotics were found to improve cognitive performance significantly in those with MCI but showed limited benefits in AD patients. The analysis highlighted the role of probiotics in reducing neuroinflammation and enhancing gut-brain axis activity. Heterogeneity among studies was significant, attributed to differences in probiotic strains, dosages, and study durations. These findings suggest probiotics as a promising intervention, particularly for early cognitive decline stages, but further robust trials are needed.

Consider incorporating probiotics (e.g., yogurt, fermented foods, or supplements with Lactobacillus and Bifidobacterium strains) into your diet to support early-stage cognitive health. This advice is based on evidence of probiotics improving cognitive function in MCI patients. Effects on advanced Alzheimer’s disease remain limited. While promising, these findings require more long-term studies for confirmation. Consult a healthcare provider for personalized guidance on supplementation.