Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

This randomized, double-blind, placebo-controlled trial examined the effects of probiotics on cognitive function and mood in healthy older adults. Over 12 weeks, participants consuming probiotics (Bifidobacterium bifidum and Bifidobacterium longum) showed improved mental flexibility and reduced stress compared to placebo. Probiotics also increased brain-derived neurotrophic factor (BDNF) levels, which are essential for learning and memory. Gut microbiota composition shifted, reducing inflammation-linked bacteria. These findings suggest probiotics may support brain health and stress-management via the gut-brain axis.

Consider adding probiotic-rich foods like yogurt or supplements with Bifidobacterium strains to your diet to support cognitive function and stress resilience. This advice is based on a controlled study showing improvements in mental flexibility and stress reduction in older adults. While promising, the study's modest sample size and short duration suggest more research is needed to confirm long-term benefits. Consult your healthcare provider before starting probiotics.