Melatonin in sleep disorders

This review examines melatonin's role in treating sleep disorders, including primary and comorbid insomnia, circadian rhythm disorders, and neurodegenerative conditions. Melatonin is most effective for sleep-onset issues and circadian rhythm alignment, particularly in older adults and those with delayed sleep phase syndrome. While prolonged-release melatonin formulations better mimic natural secretion, evidence varies for other conditions. Melatonin's safety profile supports its use under guidance, with benefits for sleep quality and related cognitive health.

Use melatonin supplements for sleep-onset issues or circadian rhythm disorders, especially in older adults or those with delayed sleep phases. Start with low doses (1-3 mg) and consult a healthcare provider for guidance. Pair melatonin use with good sleep hygiene and controlled light exposure for optimal results. Evidence supports safety but is stronger for certain conditions than others.