Life-span cognitive activity, neuropathologic burden, and cognitive aging

This study analyzed data from nearly 300 older adults to explore how engaging in cognitive activities throughout life influences cognitive decline in old age. Activities like reading, writing, and problem-solving were linked to slower cognitive decline, even after adjusting for brain pathologies such as plaques and tangles. Early-life cognitive activity, especially during childhood and middle age, also had lasting benefits. These findings suggest that lifelong mental engagement builds "cognitive reserve," helping the brain resist age-related decline and maintain better cognitive performance.

To support brain health, prioritize cognitively stimulating activities throughout life. Engage in activities like reading, learning new skills, or solving puzzles. Start early but remain active in later years to build cognitive reserve and slow mental decline. While this observational study shows strong associations, it cannot prove causation, so balance cognitive engagement with other healthy lifestyle practices like exercise and social interaction.