Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

This study investigated the effects of a cyclic ketogenic diet (KD) on aging mice. The diet, alternating weekly between KD and a regular diet, improved memory and reduced midlife mortality without increasing maximum lifespan. KD promoted neuroprotection by activating cellular pathways like PPARα, linked to energy metabolism and inflammation reduction. It preserved memory in tasks like novel object recognition and place avoidance, suggesting enhanced cognitive resilience. These findings indicate that KD can mimic fasting’s health benefits while preventing weight gain.

A ketogenic diet, periodically implemented, may support memory and healthy aging. Consult with a healthcare provider to assess individual suitability and monitor for potential long-term risks, especially if combined with existing dietary or medical needs.