Ketogenic Diet in Alzheimer’s Disease

This review examines the ketogenic diet (KD) as a potential therapy for Alzheimer’s disease (AD). KD promotes a shift from glucose to ketones as the brain's energy source, compensating for glucose metabolism impairments in AD. It reduces amyloid-beta plaques and tau tangles, decreases neuroinflammation, and enhances mitochondrial function, all of which are implicated in AD progression. Both preclinical and limited clinical studies indicate that KD may improve cognitive function and slow neurodegeneration, particularly in early stages of AD.

Consider a modified ketogenic diet under medical supervision to support brain health and potentially manage early cognitive decline. Individual responses vary, especially in those with genetic risk factors like ApoE4. Consult a healthcare provider to ensure safety and efficacy.