Ketogenic diet alleviates cognitive dysfunction and neuroinflammation in APP/PS1 mice via the Nrf2/HO-1 and NF-κB signaling pathways

This study explored the effects of a ketogenic diet (KD) on cognitive dysfunction and neuroinflammation in a mouse model of Alzheimer’s disease (AD). The KD improved memory and learning, reduced amyloid-beta plaques (a hallmark of AD), and decreased neuroinflammatory markers. Mechanistically, the diet activated the Nrf2/HO-1 pathway, enhancing the brain’s antioxidant defenses, while suppressing the pro-inflammatory NF-κB signaling. These results suggest that the KD may mitigate neurodegeneration by addressing inflammation and oxidative stress, two key factors in AD progression.

A ketogenic diet, emphasizing low carbohydrates and high healthy fats, may help reduce inflammation and support cognitive health. Consult a healthcare provider to tailor the diet to individual needs, as these findings are based on animal studies and require more validation in humans.