Investigating the evidence of prebiotic supplementation in the attenuation of age-related neurodegeneration in in vivo studies: a systematic review and meta-analysis with bayesian inference

This systematic review and meta-analysis examined the effects of probiotics and prebiotics on neurocognitive function, focusing on aging and neurodegenerative conditions. Human studies showed a modest improvement in cognitive tests like MMSE, with significant heterogeneity in outcomes. Animal studies demonstrated consistent neurocognitive improvements, such as faster escape times in maze tests. Mechanisms included anti-inflammatory effects, increased antioxidant activity, and modulation of the gut-brain axis. However, variability in study quality and funding biases highlight the need for more robust clinical trials to validate these findings.

Consider incorporating prebiotic and probiotic-rich foods like fiber-rich vegetables, yogurt, and kefir into your diet to support cognitive health and gut-brain axis balance. While human studies show promising but variable benefits for cognition, more research is needed to confirm efficacy. This approach is safe and beneficial for overall health but should not replace medical treatments for neurodegenerative conditions. Consult a healthcare provider for tailored advice.