Intermittent fasting protects against the deterioration of cognitive function, energy metabolism and dyslipidemia in Alzheimer’s disease-induced estrogen deficient rats

This study explored how intermittent fasting (IF) affects cognitive decline and metabolic health in estrogen-deficient rats with Alzheimer’s-like conditions. IF reduced memory loss, decreased beta-amyloid deposits in the hippocampus, and improved energy metabolism by enhancing fat utilization. It also lowered inflammation and improved lipid profiles but slightly worsened bone density and fasting insulin resistance. These findings suggest that IF might protect against cognitive decline and metabolic disturbances associated with estrogen deficiency and neurodegeneration.

Intermittent fasting, such as restricting eating to a 6–8 hour window daily, may support memory and metabolic health while reducing inflammation. Pair IF with a nutrient-rich diet to mitigate potential drawbacks like bone density loss. Consult a healthcare provider for guidance, especially if addressing menopause-related or neurodegenerative issues.