Intermittent Fasting Ameliorated High-Fat Diet-Induced Memory Impairment in Rats via Reducing Oxidative Stress and Glial Fibrillary Acidic Protein Expression in Brain

This study investigated the effects of intermittent fasting (IF) on rats fed a high-fat diet (HFD). IF improved memory performance and reduced oxidative stress in the brain, as evidenced by lower levels of malondialdehyde (a marker of oxidative damage) and increased glutathione (an antioxidant). The hippocampus showed improved cell viability and thickness, with less inflammation and neuronal damage. Prophylactic IF, started alongside the HFD, was more effective than curative IF, applied after damage occurred, in preserving brain health and cognitive function.

Incorporate intermittent fasting, such as alternating fasting days or a 16:8 fasting window, to potentially improve brain health and reduce oxidative stress. Pair fasting with a balanced diet to maximize benefits. As this evidence is based on animal studies, consult with a healthcare provider for human-specific applications.