Intermittent Fasting Alleviates Cognitive Impairments and Hippocampal Neuronal Loss but Enhances Astrocytosis in Mice with Subcortical Vascular Dementia

This study investigated the effects of intermittent fasting (IF) on subcortical vascular dementia (SVaD) in mice. IF improved cognitive functions, such as spatial memory, and reduced hippocampal neuronal loss compared to mice on regular diets. However, IF also increased astrocyte activity, which could indicate either neuroprotection or neuroinflammation, requiring further study. These results suggest IF might help alleviate cognitive impairments in neurovascular diseases like SVaD through mechanisms involving hippocampal health.

Intermittent fasting, such as time-restricted feeding (e.g., eating within a 6–8 hour window), may support brain health and reduce cognitive decline, especially for vascular-related issues. Pair IF with a balanced diet. While animal studies are promising, more human trials are necessary to confirm safety and effectiveness.