Intermittent calorie restriction alters T cell subsets and metabolic markers in people with multiple sclerosis

This study examined the effects of intermittent calorie restriction (CR) in people with multiple sclerosis (MS). Over eight weeks, intermittent CR reduced pro-inflammatory memory T cells and increased naïve T cells, which are crucial for immune health. It also altered key metabolic markers, such as lipid metabolites, suggesting potential benefits for reducing inflammation and improving metabolic health in MS. These findings indicate that intermittent CR could be a safe and promising dietary approach to managing MS-related inflammation and immune function.

Intermittent calorie restriction, such as the 5:2 diet (normal intake five days a week, reduced calories on two days), may help reduce inflammation and support immune health in people with MS. Consult with a healthcare provider to ensure it aligns with your health needs, as more research is needed to confirm long-term safety and benefits.