Impact of a Nutrient Formulation on Longitudinal Myelination, Cognition, and Behavior from Birth to 2 Years: A Randomized Clinical Trial

This randomized controlled trial explored how specific nutrient-enriched formulas affect brain development, behavior, and sleep in infants from birth to two years old. The study found that infants receiving a formula high in DHA, ARA, iron, vitamin B12, folic acid, and sphingomyelin exhibited increased brain myelination, especially in key brain regions involved in learning and motor control. These infants also had better sleep outcomes and less social fearfulness by 24 months. The findings emphasize how early-life nutrition can shape brain development, potentially influencing cognitive and emotional growth later in life.

Parents of young children can prioritize nutrition with essential fatty acids (DHA, ARA), iron, and vitamins B12 and folate, whether through enriched formulas or balanced diets. These nutrients may support healthy brain and behavioral development, but long-term effects on learning require further study.