Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

This study investigated how intermittent fasting (IF) alleviates diabetes-related cognitive impairment in mice. IF improved spatial memory and reduced anxiety through changes in gut microbiota and associated metabolites, enhancing mitochondrial function and synaptic health in the hippocampus. The study also identified specific metabolites like indolepropionic acid and short-chain fatty acids that contributed to these benefits. Removing gut microbiota diminished IF’s positive effects, highlighting the gut-brain connection in managing cognitive dysfunction.

Consider adopting intermittent fasting (e.g., fasting every other day or 16:8 time-restricted eating) to potentially enhance cognitive health. Pair fasting with a balanced, fiber-rich diet to support beneficial gut microbiota. As evidence in humans is limited, consult a healthcare provider before starting IF, especially if managing diabetes or other chronic conditions.