Enhancing Sleep Quality in Synucleinopathies Through Physical Exercise

This review explores how physical exercise can improve sleep quality in individuals with synucleinopathies, such as Parkinson’s disease and dementia with Lewy bodies. These conditions are marked by the buildup of α-synuclein protein in the brain, leading to motor and cognitive impairments. Sleep disturbances are common and can accelerate disease progression. Research suggests exercise may enhance neuroplasticity, reduce neuroinflammation, and aid in protein clearance, helping restore circadian rhythms. Improving sleep may not only enhance quality of life but also slow neurodegeneration.

To support brain health, regular physical activity—such as aerobic exercise, strength training, or yoga—can help regulate sleep patterns, reduce inflammation, and promote brain plasticity. While this review highlights exercise's potential, more clinical trials are needed to confirm long-term benefits in humans. Complementary strategies, such as good sleep hygiene and consistent daily routines, may further support cognitive resilience in individuals at risk of neurodegeneration.