Energy Restriction Enhances Adult Hippocampal Neurogenesis-Associated Memory after Four Weeks in an Adult Human Population with Central Obesity; a Randomized Controlled Trial

This randomized controlled trial examined how caloric restriction (CR) impacts memory and brain health in adults with central obesity. Over four weeks, both continuous and intermittent CR improved hippocampal-related memory (pattern separation), which is crucial for distinguishing similar experiences. No significant difference between the two methods was observed, though intermittent CR slightly impaired recognition memory. These findings highlight the potential for CR to enhance brain function and neurogenesis, particularly in aging populations

Adopting caloric restriction, such as reducing calorie intake or trying intermittent fasting, may support brain health and memory function. Pair this approach with a Mediterranean-style diet to maximize nutrient intake. However, consult a healthcare provider to ensure safety and suitability, as benefits and risks can vary based on individual health.