Efficacy on sleep parameters and tolerability of melatonin in individuals with sleep or mental disorders: A systematic review and meta-analysis

This systematic review and meta-analysis analyzed 34 randomized controlled trials to assess melatonin's effectiveness in improving sleep parameters and its tolerability in individuals with sleep or mental disorders. Melatonin significantly reduced sleep onset latency and increased total sleep time in children, adolescents, and adults, particularly for neurodevelopmental disorders and delayed sleep phase disorder. Melatonin was well-tolerated with no severe adverse effects reported, supporting its safety. However, heterogeneity across studies highlights the need for more standardized research.

Melatonin supplementation, under healthcare supervision, can improve sleep onset and duration, especially for those with delayed sleep phase disorder or neurodevelopmental issues. Maintaining a consistent sleep routine and reducing light exposure before bed enhances its efficacy. Current evidence supports its safety, but individual responses may vary due to study inconsistencies.