Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer’s Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study

This 12-week randomized, double-blind, active-controlled study investigated the effects of multi-strain probiotics on Alzheimer’s patients. The probiotic group showed a 36% increase in serum brain-derived neurotrophic factor (BDNF), reduced inflammatory marker IL-1β, and increased antioxidant enzyme activity (SOD), compared to minimal changes in the control group. These biomarkers are associated with improved neuron function and reduced neurodegeneration. While cognitive function showed a trend toward improvement, changes were not statistically significant. The results suggest that probiotics may enhance neuroprotection in Alzheimer’s disease.

Consider incorporating probiotic-rich foods like yogurt, kefir, or supplements with strains like Bifidobacterium and Lactobacillus to support brain health and reduce inflammation. This study highlights potential neuroprotective benefits in Alzheimer’s, but the short duration and small sample size limit conclusions. Probiotics should complement, not replace, standard Alzheimer’s treatments. Consult a healthcare provider before starting probiotics, especially for specific health conditions.