Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases

This review discusses the ketogenic diet's (KD) potential in reducing neuroinflammation and improving outcomes in neurodegenerative diseases like Alzheimer’s, Parkinson’s, ALS, and Huntington’s. KD shifts energy metabolism from glucose to ketones, reducing oxidative stress and promoting mitochondrial health. By modulating immune cell activity and decreasing inflammatory cytokines, KD shows promise in protecting neurons. Animal studies and limited clinical trials reveal cognitive and motor benefits, though long-term effects and patient adherence remain challenging.

Adopting a ketogenic diet could support brain health, particularly for those at risk of neurodegenerative diseases. Before starting, consult with a healthcare provider to ensure nutritional adequacy and address potential side effects like nutrient deficiencies or digestive discomfort.