RESOURCE
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January 15, 2020

Effects of Intermittent Fasting on Health, Aging, and Disease

Research
The New England Journal of Medicine
SUMMARY

This paper reviews the effects of intermittent fasting (IF) on overall health, aging, and disease prevention. IF cycles the body between glucose and ketone energy sources, enhancing stress resistance, reducing inflammation, and promoting cellular repair through processes like autophagy. Animal and early human studies suggest that IF improves memory, learning, and overall brain function while delaying age-related diseases like Alzheimer’s. Benefits also include improved metabolic health, reduced oxidative stress, and better vascular function.

RECOMMENDATION

Adopt a form of intermittent fasting, such as time-restricted eating (e.g., 16:8), to improve brain and metabolic health. Pair with a nutrient-rich diet for optimal benefits. Consult with a healthcare provider before beginning IF, especially for individuals with chronic conditions or unique dietary needs, as human studies are still evolving.

TAGS
intermittent fasting; brain health; aging; autophagy; ketone bodies; Alzheimer’s disease; neuroprotection; inflammation; oxidative stress; metabolic health
DEEP DIVE