Effects of intermittent fasting on cognitive health and Alzheimer’s disease

This review examines the effects of intermittent fasting (IF) on cognitive health and Alzheimer's disease (AD). IF promotes metabolic shifts, increasing ketone body use, which supports brain health by reducing inflammation, enhancing insulin sensitivity, and boosting vascular function. Animal studies show that IF reduces beta-amyloid plaques and tau protein tangles, key markers of AD, while improving memory and synaptic plasticity. Early human evidence suggests IF may improve cognitive resilience, though findings remain inconsistent and limited.

Adopting intermittent fasting, such as a 16:8 fasting-to-eating ratio, may help support brain health and reduce risks of AD. Pair IF with a nutrient-rich diet to enhance benefits. Individuals with chronic conditions or on medications should consult a healthcare provider before starting, as more human trials are needed.