Effects of Elevation of Brain Magnesium on Fear Conditioning, Fear Extinction, and Synaptic Plasticity in the Infralimbic Prefrontal Cortex and Lateral Amygdala

This study investigated the effects of magnesium-L-threonate (MgT) supplementation on fear extinction and synaptic plasticity in rats. MgT enhanced the retention of fear extinction without erasing or impairing original fear memories. The treatment boosted synaptic plasticity and increased NMDA receptor signaling and BDNF levels in the prefrontal cortex, but not in the amygdala. These findings suggest MgT’s potential as a therapeutic aid for anxiety-related disorders like PTSD, by improving fear extinction through targeted brain region modulation.

Consider dietary sources of magnesium, such as leafy greens, nuts, and seeds, to support overall brain health. While MgT shows promise in enhancing fear extinction and reducing anxiety in preclinical studies, further human research is necessary to validate its effectiveness and safety for managing conditions like PTSD.