Effects of Diet on Brain Plasticity in Animal and Human Studies: Mind the Gap

The research explores how dietary factors, including calorie restriction, intermittent fasting, polyphenols, and polyunsaturated fatty acids, influence brain plasticity in both animals and humans. These interventions improve markers like neurogenesis, synaptic function, and expression of neurotrophic factors, which are critical for learning, memory, and mood regulation. While animal studies show promising mechanisms, such as enhanced hippocampal function, human applications remain limited by translational gaps. This highlights diet as a modifiable tool for cognitive health.

Incorporating elements like moderate calorie restriction or polyphenol-rich foods (e.g., berries) and healthy fats (e.g., omega-3s) into your diet may support brain health. However, this recommendation is based on both animal and limited human studies, so its effectiveness in all populations isn't fully confirmed. Consult a healthcare provider for personalized advice.