Are ketogenic diets promising for Alzheimer’s disease? A translational review

This review explores the potential of ketogenic diets (KDs) and ketone supplementation (KS) in managing Alzheimer's disease (AD) and cognitive decline. KDs shift the brain’s energy source from glucose to ketones, reducing neuroinflammation, improving mitochondrial function, and supporting synaptic health. Animal studies demonstrate reduced amyloid and tau pathology, while human trials suggest improved cognition and memory, particularly in early AD stages. However, challenges include adherence, weight loss, and limited long-term research on safety and efficacy.

Consider a modified ketogenic diet to support brain health, especially for early cognitive decline. Consult a healthcare provider to ensure safe implementation, address nutritional needs, and monitor for potential side effects, as evidence for long-term benefits in humans remains limited.