66 The PROMOTe study: prebiotic supplementation improves cognition versus placebo in healthy older twins

The PROMOTe study, a placebo-controlled randomized trial, investigated whether a prebiotic supplement could improve cognition in healthy older twins. Over 12 weeks, one twin from each pair received protein supplementation with a prebiotic, while the other received protein with a placebo. Cognitive function, measured by the CANTAB battery, improved significantly in the prebiotic group compared to placebo. Despite more adverse events in the prebiotic group, compliance was high. These findings suggest that prebiotics can positively influence cognitive performance, likely through gut-brain axis mechanisms, in older adults with low protein intake.

Incorporate prebiotic-rich foods (e.g., bananas, asparagus, onions) into your diet to support gut health and potentially enhance cognitive function. While this study demonstrates improved cognition in older adults with prebiotic supplementation, its small sample size and specific twin-based design limit broad applicability. Prebiotics may benefit overall brain health, especially when combined with a balanced diet and regular physical activity. Consult a healthcare provider before using supplements.